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But we can stretch the analogy a step further to invoke signaling in the cell. Your hair is like a set of proteins and the gel represents ligands ions, small molecules or other proteins. OK, now wash your hands, and keep reading. Allow ligands to interact with proteins and they will reach a binding equilibrium. Say a burst of calcium ions is released in the cell in response to a biological signal and the ions bind to calcium-receptor proteins. But you can get out that excess gel and avoid bumps and splashing by thinking statistically. In essence, you have established an equilibrium between the gel in your hair and the gel on your hands. Eventually, almost all the proteins will lose their calcium ions as the signal is removed — from John Travolta to nerd.{/INSERTKEYS}{/PARAGRAPH} Put your clean maybe wet hands in your hair and rub them around to establish an equilibrium. Some of the gel is on your hands. One is to take a shower. For those of you in the business, the analogy to protein-ligand binding is obvious. We can think of a few ways to get the hair gel out of your hair. You get some gel, smear it around on your hands, and then give yourself a head massage with those gelly hands. Better smear it around your hands first, for quicker homogenous application. So you can use the principle underlying that observation to remove gel. Time to get rid of some of that gel. Recall our observation about putting in hair gel: some of it stays on your hands, in an effective equilibrium with the gel in your hair. Wash it off and repeat til you transform yourself back to a respectable nerd. {PARAGRAPH}{INSERTKEYS}We want to consider two tasks: putting hair gel in and taking it out.
